| Autor: |
Tadahiro Kobayashi, Satoko Saito, Masayuki Takada, Kento Sakaguchi, Kazunori Takahashi, Ken Tanaka, Kaneyuki Kawamae, Masaki Nakane |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Case Reports in Acute Medicine, Vol 6, Iss 1, Pp 13-18 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2504-5288 |
| DOI: |
10.1159/000533520 |
| Popis: |
Apixaban is a direct oral anticoagulation agent that exerts its effect through the direct inhibition of factor Xa. We treated a case of massive intoxication with 70 tablets of apixaban and have presented the clinical course of the associated anti-Xa activities. A 49-year-old woman was admitted to the emergency department approximately 1.5 h after impulsive self-intoxication with 175 mg of apixaban. She developed coagulopathy with prothrombin time-international normalized ratio (PT-INR) of 3.65, activated partial thromboplastin time of 56.5 s, and antithrombin activity (AT) of >150% (at 1.5 h post-ingestion). The patient’s initial and peak anti-Xa activity was 17.7 IU/mL, and its elimination displayed first-order kinetics with a half-life of 10.5 h. The patient’s anti-Xa activity was within the therapeutic dose range at 26 h post-ingestion, and she recovered without experiencing any bleeding complications. Her coagulopathy also returned to normal level at the same timing. This result suggests that PT-INR and AT can be used as substitute markers of overwhelmed anticoagulation following massive overdose of apixaban. A case of apixaban overdose with associated anti-Xa activities was presented. There was favorable resolution of anticoagulation without specific treatments. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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