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Abstract Background & Aim: Medication errors are one of the most common medical errors. Since the performance of a theory in nursing is the extent of its application for description or prediction of evidence and also its potential in handling of the results as an occasional theory this research was done to test the theoretical model of Reason human errors in nursing medication error. Materials and Methods: It was a descriptive, correlational study that was conducted at a large teaching hospital in Tehran, I.R. The nursing staffs (n = 150) were chosen in different wards affiliated to Shahid Beheshti University of Medical Sciences through convenience sampling. A researcher made questionnaire was utilized to collect demographic data, Velasquez nursing care complexity scale, Salyer work dynamic scale, Gittel et al., nurse-physician communication scale, Minick et al., work commitment scale, Wakefield et al., reporting medication error scale and Rybowiak et al., learning climate questionnaire were used to test the hypotheses related to individual and organizational factors based on Reasons Human Error Model. Using SPSS-PC (v.16), and LISREL 8.8 the data were analyzed by descriptive and path analysis tests (P_ value |