Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon.

Autor: Jordi Landier, Pascal Boisier, Félix Fotso Piam, Blanbin Noumen-Djeunga, Joseph Simé, Fidèle Gaetan Wantong, Laurent Marsollier, Arnaud Fontanet, Sara Eyangoh
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: PLoS Neglected Tropical Diseases, Vol 5, Iss 11, p e1392 (2011)
Druh dokumentu: article
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0001392
Popis: BACKGROUND: Buruli ulcer is an infectious disease involving the skin, caused by Mycobacterium ulcerans. Its exact transmission mechanism remains unknown. Several arguments indicate a possible role for insects in its transmission. A previous case-control study in the Nyong valley region in central Cameroon showed an unexpected association between bed net use and protection against Buruli ulcer. We investigated whether this association persisted in a newly discovered endemic Buruli ulcer focus in Bankim, northwestern Cameroon. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a case-control study on 77 Buruli ulcer cases and 153 age-, gender- and village-matched controls. Participants were interviewed about their activities and habits. Multivariate conditional logistic regression analysis identified systematic use of a bed net (Odds-Ratio (OR) = 0.4, 95% Confidence Interval [95%CI] = [0.2-0.9], p-value (p) = 0.04), cleansing wounds with soap (OR [95%CI] = 0.1 [0.03-0.3], p
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