Turn on fluorescence sensor for specific detection of glycoligand-receptor recognitions based graphene oxide nanocomposite

Autor: Faqiong Ou, Zhenmei Lin, Li Li, Yaoping Tang, Ziqian Zhang
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Results in Chemistry, Vol 3, Iss , Pp 100140- (2021)
Druh dokumentu: article
ISSN: 2211-7156
DOI: 10.1016/j.rechem.2021.100140
Popis: We have developed a galactosyl amino-naphthalimide based graphene oxide nanocomposite FN@GO that uses a unique mechanism: Förster resonance energy-transfer (FRET) controlled by interaction between ligands and receptors. The fluorophore stacking to surface of graphene oxide leads to a fluorescence quenching due to FRET. The galactosyl moiety of dye is a glycoligand that selectively recognized by the specific glycoprotein receptors on the surface of liver cancer cells. Therefore, our nanocomposite can provide a concise method to selectively probe HepG2 in cellular environment.
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