| Autor: |
Ivneet Banga, Durgasha C. Poudyal, Anirban Paul, Abha Sardesai, Sriram Muthukumar, Shalini Prasad |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Biosensors and Bioelectronics: X, Vol 13, Iss , Pp 100311- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2590-1370 |
| DOI: |
10.1016/j.biosx.2023.100311 |
| Popis: |
Early disease detection and diagnosis through breath-based chemical assessment is broadly studied as a non-invasive tool and used as a cutting-edge opportunity in health care. Breath analytics or Breathomics is based on the recognition of levels of metabolites such as Volatile Organic Compounds (VOCs) and inorganic gases in an exhaled human breath. Lung cancer, one such disease state, alters the concentrations of hydrocarbons released in breath due to oxidative stress and lipid pre-oxidation. Heptane can be utilized as a VOC biomarker for the non-invasive diagnosis of lung cancer. This work outlines the fabrication of a graphitic carbon nitride-based electrochemical sensor platform that possesses increased catalytic activity and can be used for the screening of heptane vapors in the range of 0.45–5 ppm limit of detection of 0.45 ppm with 95% confidence interval. The synthesized material is characterized and validated using various standard analytical methods. Chronoamperometry is employed as an electrochemical technique to examine the diffusion dynamics of the target analyte. We demonstrated the specific sensing responses of the system in the presence of interferants by executing a cross-reactivity study with respect to other commonly found interferants in breath. We effectively established the use of a graphitic carbon nitride-based electrochemical sensor for point-of-care screening (qualitative analysis with p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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