Novel 4-benzoylpyridine oxime derivative GIZH-298 with aticonvulsant activity

Autor:	L. A. Zhmurenko, G. V. Mokrov, L. N. Nerobkova, S. A. Litvinova, I. O. Gaydukov, T. A. Voronina, T. A. Gudasheva
Jazyk:	ruština
Rok vydání:	2017
Předmět:	противосудорожные средства оксимы бензоилпиридинов тест максимального электрошока тест антагонизма с коразолом anticonvulsant drugs benzoylpyridine oximes maximal electroshock test corazol antagonism test Pharmacy and materia medica RS1-441
Zdroj:	Фармакокинетика и Фармакодинамика, Vol 0, Iss 1, Pp 22-26 (2017)
Druh dokumentu:	article
ISSN:	2587-7836 2686-8830
Popis:	Novel derivative of benzoylpyridine oximes - GIZH-298 (4-benzoylpyridine 0-(2-morpholinoethyl) oxime oxalate) was designed and synthesized in this work. This compound has a broad spectrum of anticonvulsant effects, eliminating primary generalized seizures in maximal electroshock (MES) and corazol antagonism tests in rodents in the doses of 0,5-100 mg/kg. LD50 for compound GIZH-298 is 316 mg/kg intraperitoneally (mouse). GIZH-298 has a large therapeutic breadth.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7e930911f8374b798f0796275a46c084 Zobrazit plný text záznamu View record in DOAJ