Generation of a human iPSC cell line (MUSIi017-A) from a donor with O negative blood type

Autor: Nittaya Jiamvoraphong, Chanchao Lorthongpanich, Phatchanat Klaihmon, Pakpoom Kheolamai, Surapol Issaragrisil
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Stem Cell Research, Vol 78, Iss , Pp 103466- (2024)
Druh dokumentu: article
ISSN: 1873-5061
DOI: 10.1016/j.scr.2024.103466
Popis: The Rh-negative type O blood group (O Rh-) is considered a universal donor for emergency blood transfusions. Due to the constant shortage of this rare blood group, the production of blood cells from iPSCs derived from the O Rh- donor could potentially serve as a limitless blood source for transfusions. In this report, we establish a MUSIi017-A iPSC line from peripheral blood mononuclear cells of a healthy donor with the O Rh- blood group. The established iPSC line exhibited a normal karyotype, showed identical STR compared to donor peripheral blood mononuclear cells, and could differentiate to all three germ layers.
Databáze: Directory of Open Access Journals