The physiological and pathological properties of Mead acid, an endogenous multifunctional n-9 polyunsaturated fatty acid

Autor:	Hiroshi Kawashima, Katsuhiko Yoshizawa
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Mead acid Eicosatrienoic acid n-9 Arachidonic acid Essential fatty acid Polyunsaturated fatty acid Nutritional diseases. Deficiency diseases RC620-627
Zdroj:	Lipids in Health and Disease, Vol 22, Iss 1, Pp 1-10 (2023)
Druh dokumentu:	article
ISSN:	1476-511X
DOI:	10.1186/s12944-023-01937-6
Popis:	Abstract Mead acid (MA, 5,8,11-eicosatrienoic acid) is an n-9 polyunsaturated fatty acid (PUFA) and a marker of essential fatty acid deficiency, but nonetheless generally draws little attention. MA is distributed in various normal tissues and can be converted to several specific lipid mediators by lipoxygenase and cyclooxygenase. Recent pathological and epidemiological studies on MA raise the possibility of its effects on inflammation, cancer, dermatitis and cystic fibrosis, suggesting it is an endogenous multifunctional PUFA. This review summarizes the biosynthesis, presence, metabolism and physiological roles of MA and its relation to various diseases, as well as the significance of MA in PUFA metabolism.
Databáze:	Directory of Open Access Journals
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