Incidence rates of dilated cardiomyopathy in adult first-degree relatives versus matched controls

Autor: Charlotte Andersson, Morten Schou, Brian Schwartz, Ramachandran S. Vasan, Mia Nielsen Christiansen, Maria D'Souza, Peter Weeke, Lars Køber, Alex H. Christensen, Gunnar H. Gislason, Christian Torp-Pedersen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: International Journal of Cardiology: Heart & Vasculature, Vol 41, Iss , Pp 101065- (2022)
Druh dokumentu: article
ISSN: 2352-9067
DOI: 10.1016/j.ijcha.2022.101065
Popis: Background: The incidence rates and importance of traditional risk factors in dilated cardiomyopathy among first-degree relatives are unknown. Methods and Results: We identified all probands with dilated cardiomyopathy (n = 13,714, mean age at diagnosis 63 years) from the Danish nationwide registries between 1994 and 2017. Incidence rates among first-degree relatives (n = 29,671, mean age 38 years) and for up to 10 age- and sex-matched controls were calculated. Totally 233 (0.8%) first-degree relatives and 285 (0.1%) controls developed dilated cardiomyopathy during a median follow-up of 8.2 (Q1-Q3 4.4–13.3) years. Incidence rates (per 100,000 person-years) were 86.4 (95% confidence interval 73.9–101.0) and 111.1 (79.4–128.7) for first-degree relatives aged
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