| Autor: |
Hirofumi Bekki, Yoshihiro Matsumoto, Masato Yoshimoto, Shin Ishihara, Kenichi Kawaguchi, Hidetaka Yamamoto, Yoshinao Oda, Yasuharu Nakashima, Katsumi Harimaya |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Spine Surgery and Related Research, Vol 7, Iss 1, Pp 36-41 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2432-261X |
| DOI: |
10.22603/ssrr.2022-0063 |
| Popis: |
Introduction: Tumor size is an important factor in determining the appropriate clinical management of intradural-extramedullary schwannoma. A tumor volume reduction may be achieved by conservative targeted therapy instead of invasive surgery if a molecular event related to tumor size is discovered. Insulin-like growth factor II messenger RNA-binding protein 3 (IMP3), an oncofetal tumor-associated antigen that is expected to be a target for immunotherapy, was focused on in this study. Methods: The IMP3 status was assessed by immunohistochemistry in 64 samples of intradural-extramedullary schwannoma, and the correlation between IMP3 expression and tumor size was evaluated. Results: Immunohistochemically, high IMP3 expression was observed in ～85% of schwannomas. The maximum tumor diameter of the high IMP3 expression group was significantly larger than that of the low IMP3 expression group (34.3 mm vs 18.5 mm, p=0.002). The receiver operating characteristic curve demonstrated that a maximum tumor diameter of 24 mm was a predictable factor for IMP3 expression (sensitivity, 0.7; 1−specificity, 0.2; area under the curve, 0.82). Conclusions: Upregulated IMP3 expression was associated with large tumor size, suggesting a possible therapeutic approach. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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