Single molecule mechanics resolves the earliest events in force generation by cardiac myosin

Autor:	Michael S Woody, Donald A Winkelmann, Marco Capitanio, E Michael Ostap, Yale E Goldman
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	myosin optical trap cardiac myosin phosphate release working stroke strong binding Medicine Science Biology (General) QH301-705.5
Zdroj:	eLife, Vol 8 (2019)
Druh dokumentu:	article
ISSN:	2050-084X
DOI:	10.7554/eLife.49266
Popis:	Key steps of cardiac mechanochemistry, including the force-generating working stroke and the release of phosphate (Pi), occur rapidly after myosin-actin attachment. An ultra-high-speed optical trap enabled direct observation of the timing and amplitude of the working stroke, which can occur within
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7e6497584f8c4b5f9f10fe21aaa0176a Zobrazit plný text záznamu View record in DOAJ