Features of systemic sclerosis-rheumatoid arthritis overlap syndrome (SS-RA overlap syndrome)
| Autor: | O. V. Desinova, M. N. Starovoytova, I. A. Guseva, A. A. Novikov, E. N. Alexandrova, N. G. Guseva |
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| Jazyk: | ruština |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Научно-практическая ревматология, Vol 45, Iss 4, Pp 18-23 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1995-4484 1995-4492 |
| DOI: | 10.14412/1995-4484-2007-18-23 |
| Popis: | Objective. To reveal clinico-laboratory, immunologic and immunogenetic features of systemic sclerosis-rheumatoid arthritis overlap syndrome (SS-RA).Material and methods. 32 pts with SS-RA (1 male, 31 female) aged 22 to 74 years with disease onset at 18 to 69 years and disease duration from 1 to 35 years were included. Complex laboratory and instrumental examination was performed including nailfold capillaroscopy. A part of pts was also evaluated with magnetic resonance imaging of hands. Serum level of rheumatoid factor, antinuclear factor, circulating immune complexes, C-reactive protein, antibodies to cyclic citrullinated peptide (ACCP) was evaluated. Genotyping of DRB1 alleles was performed.Results. Characteristic features of SS-RA were prevalence of limited skin damage, less prominent peripheral and visceral symptoms of SS, presence of anti-topoisomerase antibodies and erosive arthritis, high laboratory and immunological activity, more frequent association with DRB1*01.Conclusion. SS-RA possesses its own clinical features and can be considered as a distinct subtype of SS. |
| Databáze: | Directory of Open Access Journals |
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