Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure

Autor: Laura Verbree‐Willemsen, Ya‐nan Zhang, Irwani Ibrahim, Shirley B.S. Ooi, Jiong‐Wei Wang, Muhammad I. Mazlan, Win S. Kuan, Siew‐Pang Chan, Linda M. Peelen, Diederick E. Grobbee, A. Mark Richards, Carolyn S.P. Lam, Dominique P.V. deKleijn
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: ESC Heart Failure, Vol 7, Iss 5, Pp 2240-2249 (2020)
Druh dokumentu: article
ISSN: 2055-5822
DOI: 10.1002/ehf2.12699
Popis: Abstract Aims Extracellular vesicles (EVs) are small double‐membrane plasma vesicles that play key roles in cellular crosstalk and mechanisms such as inflammation. The role of EVs in combined organ failure such as cardiorenal syndrome has not been investigated. The aim of this study is to identify EV proteins that are associated with renal dysfunction, heart failure, and their combination in dyspnoeic patients. Methods and results Blood samples were prospectively collected in 404 patients presenting with breathlessness at the emergency department at National University Hospital, Singapore. Renal dysfunction was defined as estimated glomerular filtration rate
Databáze: Directory of Open Access Journals