| Autor: |
Maximilian Eichner, Henri Wallaschofski, Ulf Schminke, Henry Völzke, Marcus Dörr, Stephan B Felix, Matthias Nauck, Nele Friedrich |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Endocrine Connections, Vol 182, Iss 1, Pp 79-90 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2049-3614 |
| DOI: |
10.1530/EJE-19-0470 |
| Popis: |
Objective: Several studies revealed relations between low or high insulin -like growth factor I (IGF-I) levels and risk of cardiovascular diseases or mortality, whereas the mechanisms be hind these associations are still unknown. Design: The study aimed to explore the relations between IGF-I and cha nges in surrogate markers of cardiovascular disease including carotid intima-media thickness (IMT), left ve ntricular mass index (LVMI) and N-terminal pro-brain natriuretic peptide (NT-proBNP). Methods: Longitudinal data of the population-based cohort Study of Heal th in Pomerania (SHIP) were used. IMT was measured by ultrasonography and LVMI was determined based on ec hocardiography. IGF-I and IGF-binding protein-3 (IGFBP-3) levels were measured by chemiluminescent immunoassays and the IGF-I/IGFBP-3 ratio was calculated. Mixed linear regression models adjusted for known cardiovascular conf ounders were performed. Results: Statistical analyses demonstrated relations between low baseli ne IGF-I levels (beta for ΔIMT per s.d. increase −0.044 (s.e. 0.012)) or IGF-I/IGFBP-3 ratio (beta −0.045 (0.012)) and a long-term IMT increase. No associations be tween IGF-I, IGFBP-3 or IGF-I/IGFBP-3 ratio and changes in LVMI were detected. With respect to NT-proBNP sex-specific associations with IGF-I were found. In women, higher baseline I GF-I levels (beta for ΔNT-proBNP per s.d. increase 5.92 (2.2)) or IGF-I/IGFBP-3 ratio (beta 4.48 (2.2)) were related to an increase in NT-proBNP levels. Among men, U-shaped relations of baseline levels of IGF-I, IGFBP-3 and the IGF-I/IG FBP-3 ratio with an increase in NT-proBNP were found. Conclusions: The study detected significant relations between IGF-I and long -term changes in IMT and NT-proBNP but not LVMI. These findings argue for different effects of the IGF-I axis with respect to various cardiovascular entities. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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