| Autor: |
James E. Fulton, Jr., S.L. Hsia |
| Jazyk: |
angličtina |
| Rok vydání: |
1972 |
| Předmět: |
|
| Zdroj: |
Journal of Lipid Research, Vol 13, Iss 1, Pp 78-85 (1972) |
| Druh dokumentu: |
article |
| ISSN: |
0022-2275 |
| DOI: |
10.1016/S0022-2275(20)39440-2 |
| Popis: |
The effects of clofibrate (ethyl p-chlorophenoxyisobutyrate) on lipid synthesis by human skin were studied in vitro. The drug was found to inhibit lipid synthesis from [1-14C]acetate or [U-14C]glucose. While the synthesis of all classes of lipids was suppressed, inhibition of sterol synthesis was more pronounced than that of fatty acids and glycerides. By comparison, sodium p-chlorophenoxyisobutyrate was less effective as an inhibitor.The addition of glucose to the incubation medium enhanced lipid synthesis from both [1-14C]acetate and [U-14C]glucose. The inhibitory effect of clofibrate could be partially reversed by increasing the glucose concentration in the incubation medium.Rat skin and rat liver were studied similarly, using [1-14C]acetate as a tracer for lipid synthesis, and the inhibitory effect of clofibrate was also demonstrated. Of the three tissues studied, human skin was the most sensitive to the drug and yielded more reproducible results. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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