Identification of a differential metabolite-based signature in patients with late-stage knee osteoarthritis

Autor: Jason S. Rockel, Mehdi Layeghifard, Y. Raja Rampersaud, Anthony V. Perruccio, Nizar N. Mahomed, J. Roderick Davey, Khalid Syed, Rajiv Gandhi, Mohit Kapoor
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Osteoarthritis and Cartilage Open, Vol 4, Iss 3, Pp 100258- (2022)
Druh dokumentu: article
ISSN: 2665-9131
DOI: 10.1016/j.ocarto.2022.100258
Popis: Objective: Multiple disease phenotypes have been identified in knee osteoarthritis (OA) patients based on anthropometric, sociodemographic and clinical factors; however, differential systemic metabolite-based signatures in OA patients are not well understood. We sought to identify differential plasma metabolome signatures in a cross-sectional sample of late-stage knee OA patients. Methods: Plasma from 214 (56.5% female; mean age ​= ​67.58 years) non-diabetic, non-obese (BMI
Databáze: Directory of Open Access Journals