Clinical application of platelet rich plasma to promote healing of open hand injury with skin defect

Autor: Xinhui Du, Jiarui Zhao, Qian Ren, Yibo Ma, Pengxia Duan, Yansheng Huang, Sibo Wang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Regenerative Therapy, Vol 26, Iss , Pp 308-314 (2024)
Druh dokumentu: article
ISSN: 2352-3204
DOI: 10.1016/j.reth.2024.06.003
Popis: Background: Skin defects caused by open hand trauma are difficult to treat clinically and severely affect the recovery of hand function. Autologous platelet-rich plasma (PRP) has been widely used in the treatment of refractory chronic wounds, but its use in hand trauma skin defects remains scarce. Methods: This study compared the outcomes of 27 patients treated with PRP to 31 patients undergoing skin flap transplantation for hand wounds. We assessed several parameters, including healing times, duration of surgery, postoperative pain (VAS score), intraoperative amputation length, finger function, sensation restoration, nail bed preservation, and hospitalization expenses. Results: PRP-treated patients showed a mean healing time of 21.59 ± 3.17 days. Surgical times were significantly shorter in the PRP group (22.04 ± 7.04 min) compared to the flap group (57.45 ± 8.15 min, P
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