Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
Autor: | Dalia Charles-Navarro, Virgilio Bocanegra-García, Isidro Palos, Gildardo Rivera, Patricia Esquivel-Ferriño, Sandra Gracia-Vásquez, Rolffy Ortiz-Andrade, Jesús Quiroz-Velásquez, José Luis Hernández-Mendoza |
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Jazyk: | English<br />Spanish; Castilian<br />Portuguese |
Rok vydání: | 2010 |
Předmět: | |
Zdroj: | Química Nova, Vol 33, Iss 7, Pp 1435-1439 (2010) |
Druh dokumentu: | article |
ISSN: | 0100-4042 1678-7064 |
DOI: | 10.1590/S0100-40422010000700002 |
Popis: | The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties. |
Databáze: | Directory of Open Access Journals |
Externí odkaz: |
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