Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads

Autor: Dalia Charles-Navarro, Virgilio Bocanegra-García, Isidro Palos, Gildardo Rivera, Patricia Esquivel-Ferriño, Sandra Gracia-Vásquez, Rolffy Ortiz-Andrade, Jesús Quiroz-Velásquez, José Luis Hernández-Mendoza
Jazyk: English<br />Spanish; Castilian<br />Portuguese
Rok vydání: 2010
Předmět:
Zdroj: Química Nova, Vol 33, Iss 7, Pp 1435-1439 (2010)
Druh dokumentu: article
ISSN: 0100-4042
1678-7064
DOI: 10.1590/S0100-40422010000700002
Popis: The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with two commercially available trademarks (Daonil® and Glibetab®). We obtained glibenclamide loaded calcium-alginate beads with a rough surface and a particle size between 150-200 µm. For the in vitro dissolution test Daonil® at 45 min showed a Q > 70%, whereas Glibetab® and glibenclamide calcium-alginate beads a Q < 70%; in spite of that glibenclamide calcium-alginate beads showed significant release properties.
Databáze: Directory of Open Access Journals
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