Polyoxygenated Terpenoids and Polyketides from the Roots of Flueggea virosa and Their Inhibitory Effect against SARS-CoV-2-Induced Inflammation

Autor:	Ju-Chien Cheng, Yi-Ju Chen, Chi-Wen Chuang, Ya-Hsuan Chao, Hui-Chi Huang, Chia-Chi Lin, Chih-Hua Chao
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	SARS-CoV-2 anti-inflammatory podovirosanes A–F Flueggea virosa DP4+ Organic chemistry QD241-441
Zdroj:	Molecules, Vol 27, Iss 23, p 8548 (2022)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules27238548
Popis:	Six new polyoxygenated terpenoids, podovirosanes A–F (1–6), and two known polyketides (7 and 8) were isolated from the roots of F. virosa. Their structures, along with absolute configurations, were deduced using spectroscopic analysis as well as computational calculations, including TDDFT calculation of ECD spectra and GIAO NMR calculations combined with DP4+ probability analysis. Compounds 2, 3, 5, and 8 were found to reduce the phosphorylation levels of NF-κB p65 in SARS-CoV-2 pseudovirus-stimulated PMA-differentiated THP-1 cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7e1ca33d041e4431a49ba29c27b171ea Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.