A case of acute functional hemispherotomy in a young woman with hemimegalencephaly and super-refractory status epilepticus

Autor: Kjell Heuser, Luis Romundstad, Jugoslav Ivanovic, Arild Egge, Erik Sætre, Kristin Alfstad, Line Sveberg, Line Bedos Ulvin, Erik Taubøll
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Epilepsy & Behavior Reports, Vol 28, Iss , Pp 100728- (2024)
Druh dokumentu: article
ISSN: 2589-9864
DOI: 10.1016/j.ebr.2024.100728
Popis: Status epilepticus (SE) is a critical medical emergency that demands immediate and effective intervention. We report a unique case involving a 21-year-old woman with left hemimegalencephaly who was hospitalized for super-refractory status epilepticus (SRSE) that persisted for 8 weeks. Despite extensive treatment efforts including multiple anti-seizure medications, anesthetics, high-dose methylprednisolone, anakinra, magnesium infusion, and a ketogenic diet, her condition remained unchanged. Ultimately, a left functional hemispherotomy was performed, informed by MRI findings and EEG results showing predominantly left-sided epileptic activity. This decision was made collaboratively when all other therapeutic options had been exhausted. Postoperatively, the patient recovered with manageable neurological deficits and a satisfactory quality of life. To our knowledge, this is the first reported case of acute functional hemispherotomy in an adult with hemimegalencephaly and SRSE.
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