Changes in plasma aldosterone level after weight loss by bariatric surgery in morbidly obese patients

Autor:	Preaw Suwannasrisuk, Patchaya Boonchaya-anant, Natnicha Houngngam, Suthep Udomsawaengsup, Sarat Sunthornyothin
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Plasma aldosterone concentration Direct renin concentration Renin–angiotensin–aldosterone system Bariatric surgery Obesity Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	BMC Endocrine Disorders, Vol 20, Iss 1, Pp 1-6 (2020)
Druh dokumentu:	article
ISSN:	1472-6823
DOI:	10.1186/s12902-020-0527-4
Popis:	Abstract Background Overactivation of renin-aldosterone-angiotensin system (RAS) is part of the pathogenesis of obesity-associated hypertension. Evidences have shown that weight loss can result in reduction in blood pressure and RAS. This study was aim to investigate changes of plasma aldosterone concentration (PAC) after bariatric surgery. Methods A prospective study was done in 14 morbidly obese patients undergoing bariatric surgery. Patients who were taking medications that can interfere with PAC and renin levels were excluded. Collection of blood samples were done at baseline and at 3 and 6-month post-bariatric surgery. Results Four out of 14 patients had hypertension at baseline. Mean body mass index (BMI) was 56.7 ± 13.5 kg/m2. PAC were significantly decreased at 3-and 6-month post-bariatric surgery from 14.3 ± 8.0 to 7.5 ± 5.5 [reduction of 36% from baseline (P
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