Autor: |
Raghunanthan Jagannathan, Thodur Madapusi Balaji, Suresh Ranga Rao, Meshal Saleh Alosaimi, Shankargouda Patil, Yuliia Siurkel, Marco Cicciù, Giuseppe Minervini |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
BMC Oral Health, Vol 24, Iss 1, Pp 1-9 (2024) |
Druh dokumentu: |
article |
ISSN: |
1472-6831 |
DOI: |
10.1186/s12903-023-03793-3 |
Popis: |
Abstract Monocytes and their macrophage progeny are thought to be involved in tissue and alveolar bone destruction in periodontal disease. It has been documented that the proportion of (CD14 + CD16+) non-classical monocytes in the blood are elevated in chronic periodontitis;A total of 20 chronic generalized periodontitis patients who were otherwise healthy, were recruited for this study. At baseline and 3 weeks after non-surgical periodontal treatment, peripheral blood was obtained to assess the levels of C-reactive protein (CRP) and the proportion of monocyte subsets. Monocyte subsets were assessed using flow cytometry;The mean percentage of CD14 + CD16+ non-classical monocytes in the peripheral blood sample at baseline was 13.95 + 2.09, that reduced to 8.94 + 1.23 3 weeks after non-surgical treatment. A distinct significant reduction in the percentage of non-classical monocytes and a concomitant increase in classical monocytes were observed following periodontal treatment compared to baseline. There was a significant reduction in the all the periodontal parameters and CRP levels 3 weeks post non-surgical periodontal treatment. A positive correlation between CRP and percentage of non-classical monocytes was also observed; Periodontal treatment potentially modulates the host response effectively. |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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