Cytological, histopathological and immunohistochemical features of merkel cell carcinoma- A case report

Autor: Pooja Chauhan, Neelam Gupta, Kavita Mardi, Sudershan Kumar Sharma, Anita Negi
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Archives of Medicine and Health Sciences, Vol 6, Iss 1, Pp 122-125 (2018)
Druh dokumentu: article
ISSN: 2321-4848
DOI: 10.4103/amhs.amhs_27_18
Popis: Merkel cell carcinoma (MCC) is a rare, potentially aggressive primary cutaneous neuroendocrine carcinoma. MCC commonly occurs on sun-exposed skin in fair-skinned elderly individuals. It usually presents as a banal-appearing lesion, and the diagnosis is rarely suspected at the time of biopsy. We describe the cytomorphologic, histopathological, and immunohistochemical characteristics of MCC in a 76-year-old male patient presenting with rapidly evolving large red raised lesion over cheek for 1 month. Cytohistopathological evaluation suggested MCC. Immunohistochemistry revealed that the tumor cells were negative for leukocyte common antigen, S-100 protein, HMB45, and cytokeratin 20 and positive for neuron specific enolase. Because of the documented aggressiveness and rising incidence, early diagnosis of this rare tumor is necessary for the management of MCC.
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