Diamond-Like Carbon Depositing on the Surface of Polylactide Membrane for Prevention of Adhesion Formation During Tendon Repair

Autor:	Yao Xiao, Zaijin Tao, Yufeng Ju, Xiaolu Huang, Xinshu Zhang, Xiaonan Liu, Pavel A. Volotovski, Chao Huang, Hongqi Chen, Yaozhong Zhang, Shen Liu
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Diamond-like carbon Reactive oxygen species scavenging Foreign body reaction Biodegradation Antioxidant Peritendinous adhesion Technology
Zdroj:	Nano-Micro Letters, Vol 16, Iss 1, Pp 1-22 (2024)
Druh dokumentu:	article
ISSN:	2311-6706 2150-5551
DOI:	10.1007/s40820-024-01392-7
Popis:	Highlights The anti-adhesion effect of polylactic acid (PLA) membrane with diamond-like carbon (DLC) depositing is 44.72%, enhanced by 23.11% compared to PLA. DLC deposited on PLA membranes has been shown to effectively reduce the levels of reactive oxygen species, leading to a decrease in the expression of pro-inflammatory cytokines within peritendinous adhesion tissue. DLC decelerates PLA biodegradation and lactic production, which reduces the number of CD68+CD206+ macrophages within peritendinous adhesion tissue.
Databáze:	Directory of Open Access Journals
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