Red Blood Cell Alloimmunization in Pediatric group with Beta Thalassemia: A Five-Year Experience
| Autor: | Kiran Minhas MBBS FCPS, Muzamil Shabana Ejaz MBBS MCPS DCH FCPS, Alaa Tukruna MD, Maryam Haider MBBS FCPS, Aabiya Arif MBBS, Sameer Saleem Tebha MBBS |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Global Pediatric Health, Vol 9 (2022) |
| Druh dokumentu: | article |
| ISSN: | 2333-794X 2333794X |
| DOI: | 10.1177/2333794X221132679 |
| Popis: | Beta-thalassemia is one of the most frequently occurring hematological disorders in [Removed for blinded peer-review]. Regular blood transfusion is required in almost all cases for management. However, this is associated with significant major complications like red blood cell (RBC) alloimmunization. This retrospective cross-sectional is conducted to evaluate the RBC alloimmunization frequency in children with beta-thalassemia aged between 6 months and 16 years in [Removed for blinded peer-review]. Antibody screening was performed using the Dia clon3 cell antigen panel. If the screening came back positive, a detailed panel was created for the identification of specific antibody. In our sample, the frequency of RBC alloimmunization was found in 22 (26.19%) patients. Of these 22 patients, the Rhesus system was found in most patients 17 (77.3%), followed by Kell 5 (22.7%). RBC alloimmunization was significantly associated with a family history of a blood disorder and splenectomy. |
| Databáze: | Directory of Open Access Journals |
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