Evaluation of the VKORC 1 and CYP2C9 Gene Polymorphisms and Their Effects on the Emergency Complications in the Patients Using Warfarin
| Autor: | Oğuz Yardım, Emine Emektar, Yunsur Çevik, Şeref Kerem Çorbacıoğlu, Ali Ekber Karabulut |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Eurasian Journal of Emergency Medicine, Vol 16, Iss 2, Pp 65-69 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2149-5807 2149-6048 |
| DOI: | 10.5152/eajem.2017.18209 |
| Popis: | Aim: We aimed to evaluate the effects of genetic polymorphisms on the frequency of application to the emergency service and on the complications with use of warfarin in this study.Materials and Methods: Seventy patients were included in the study. Two groups were composed: one group of 40 patients who used warfarin and with international normalized ratios (INRs) ≥3.5 IU and a second group of 30 control group patients with normal INR levels. Blood samples were examined through the warfarin dosage sensitivity test.Results: VKORC 1 heterozygote type AG was the most frequently seen allele in 17 of the haplotype patients (42.5%), in 12 of the control group patients (40%), in 21 of the CYP2C9 *1/*1 patients (52.5%), and in 17 of the CYP2C9 *1/*1 control group patients. No statistically significant difference was identified between the groups (p>0.05). No statistically significant relationship was established as regards the frequency of emergency service visits and bleeding complications with CYP2C9 and VKORC 1 genes.Conclusion: The most common haplotypes VKORC 1 heterozygote type AG and CYP2C9 *1/*1. No relationship was identified between INR levels and VKORC 1 and CYP2C9 haplotypes. These genes have no effect on bleeding and frequent applications of emergency service. |
| Databáze: | Directory of Open Access Journals |
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