Aetiological distribution of pulmonary hypertension and the value of transthoracic echocardiography screening in the respiratory department: A retrospective analysis from China

Autor: Cheng Hong, Riken Chen, Linna Hu, Haimin Liu, Jianmin Lu, Chunying Zhuang, Wenliang Guo, Xiaofeng Wu, Jielong Lin, Xishi Sun, Haiyang Tang, Zhewen Wang, Nuofu Zhang, Zhenzhen Zheng
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: The Clinical Respiratory Journal, Vol 17, Iss 6, Pp 536-547 (2023)
Druh dokumentu: article
ISSN: 1752-699X
1752-6981
DOI: 10.1111/crj.13623
Popis: Abstract Methods The aetiological composition and clinical characteristics of patients with pulmonary hypertension (PH) hospitalised in the respiratory department were retrospectively analysed, as well as the correlation between transthoracic echocardiography (TTE) and right heart catheterization (RHC) for evaluating pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP). Results Of 731 patients, 544 (74.42%) were diagnosed with PH by RHC. Pulmonary arterial hypertension (PAH) was the most common type of PH, accounting for 30.10%; PH due to lung disease and/or hypoxia accounted for 20.79%, and PH due to pulmonary artery obstructions accounted for 19.29%. TTE has the highest specificity for diagnosing PH due to pulmonary artery obstructions. The specificity was 0.9375, the sensitivity was 0.7361 and the area under the ROC curve (AUC) was 0.836. PASP, and mPAP estimated by TTE were different for various types of PH. In terms of PASP, TTE overestimated PASP in PH due to lung disease and/or hypoxia, but there was no significant difference compared with RHC (P > 0.05). TTE underestimates PAH patients' PASP compared with RHC. In terms of mPAP, TTE underestimated the mPAP of all types of PH, as there was a significant difference in the TTE‐estimated mPAP of patients with PAH compared with RHC but not on other types of PH. Pearson correlation analysis of TTE and RHC showed a moderate overall correlation (rPASP 0.598, P
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