Potent and conditional redirected T cell killing of tumor cells using Half DVD-Ig

Autor: Philip D. Bardwell, Matthew M. Staron, Junjian Liu, Qingfeng Tao, Susanne Scesney, Gail Bukofzer, Luis E. Rodriguez, Chee-Ho Choi, Jennifer Wang, Qing Chang, Feng Dong, Cherrie Donawho, Jieyi Wang, Christine M. Grinnell, Edit Tarcsa, Charles Hutchins, Tariq Ghayur, Jijie Gu
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Protein & Cell, Vol 9, Iss 1, Pp 121-129 (2017)
Druh dokumentu: article
ISSN: 1674-800X
1674-8018
DOI: 10.1007/s13238-017-0429-z
Popis: Abstract Novel biologics that redirect cytotoxic T lymphocytes (CTLs) to kill tumor cells bearing a tumor associated antigen hold great promise in the clinic. However, the ability to safely and potently target CD3 on CTL toward tumor associated antigens (TAA) expressed on tumor cells remains a challenge of both technology and biology. Herein we describe the use of a Half DVD-Ig format that can redirect CTL to kill tumor cells. Notably, Half DVD-Ig molecules that are monovalent for each specificity demonstrated reduced non-specific CTL activation and conditional CTL activation upon binding to TAA compared to intact tetravalent DVD-Ig molecules that are bivalent for each specificity, while maintaining good drug like properties and appropriate PK properties.
Databáze: Directory of Open Access Journals
Externí odkaz: