| Autor: |
Li Li, Xi Zhang, Minhu Chen, Zhirong Zeng, Shenghong Zhang, Rirong Chen, Qia Chen, Yizhe Tie, Jianwu Zhang, Pinwei Huang, Yuxuan Xie, Liqian Zhang, Xueer Tang |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
BMJ Open Gastroenterology, Vol 11, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2054-4774 |
| DOI: |
10.1136/bmjgast-2024-001497 |
| Popis: |
Objective Serum amyloid A (SAA) was found to be positively correlated with the activity of Crohn’s disease (CD); however, its prognostic value remains uncertain. Here, we examined its predictive ability in newly diagnosed CD and explored genetic association.Methods This retrospective cohort study included patients newly diagnosed as CD at the First Affiliated Hospital of Sun Yat-sen University between June 2010 and March 2022. We employed receiver operating characteristic curve, Cox proportional hazard regression models and restricted cubic splines to investigate the prognostic performance of SAA for surgery and disease progression. To assess possible causality, a two-sample Mendelian randomisation (MR) of published genome-wide association study data was conducted.Results During 2187.6 person-years (median age, 28 years, 72.4% male), 87 surgery and 153 disease progression events were documented. A 100-unit increment in SAA level generated 14% higher risk for surgery (adjusted HR (95% CI): 1.14 (1.05–1.23), p=0.001) and 12% for disease progression (1.12 (1.05–1.19), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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