Components with Anti-Diabetic Activity Isolated from the Leaves and Twigs of Glycosmis pentaphylla Collected in Vietnam

Autor:	Minh Tuyet Thi Nguyen, I-Chi Hsu, Hui-Kang Liu, Yu-Chi Lin, Shu-Rong Chen, Fang-Rong Chang, Yuan-Bin Cheng
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Glycosmis pentaphylla anti-diabetes GLP-1 DPP4 Medicine Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceuticals, Vol 15, Iss 12, p 1543 (2022)
Druh dokumentu:	article
ISSN:	1424-8247
DOI:	10.3390/ph15121543
Popis:	A phytochemical investigation of the leaves and twigs of Glycosmis pentaphylla (Rutaceae), collected in Vietnam, yielded three new compounds named glyfuran (1), glyphyllamide (2), and glyphyllazole (3), along with twenty-five known compounds (4–28). The structures of isolates were determined by IR, MS, NMR, and UV data analyses. In the anti-diabetic activity screening, (+)-isoaltholacton (4), glycoborinine (17), 2′,4′-dihydroxy-4,6′-dimethoxychalcone (24), and flavokawain A (25) simultaneously exhibited inhibition of dipeptidyl peptidase-4 (DPP4) and stimulation of the glucagon-like peptide-1 (GLP-1) secretion on the murine intestinal secretin tumor cell line (STC-1).
Databáze:	Directory of Open Access Journals
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