| Autor: |
Shixian Hu, Arno R. Bourgonje, Ranko Gacesa, Bernadien H. Jansen, Johannes R. Björk, Amber Bangma, Iwan J. Hidding, Hendrik M. van Dullemen, Marijn C. Visschedijk, Klaas Nico Faber, Gerard Dijkstra, Hermie J. M. Harmsen, Eleonora A. M. Festen, Arnau Vich Vila, Lieke M. Spekhorst, Rinse K. Weersma |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-024-45855-2 |
| Popis: |
Abstract Disrupted host-microbe interactions at the mucosal level are key to the pathophysiology of IBD. This study aimed to comprehensively examine crosstalk between mucosal gene expression and microbiota in patients with IBD. To study tissue-specific interactions, we perform transcriptomic (RNA-seq) and microbial (16S-rRNA-seq) profiling of 697 intestinal biopsies (645 derived from 335 patients with IBD and 52 from 16 non-IBD controls). Mucosal gene expression patterns in IBD are mainly determined by tissue location and inflammation, whereas the mucosal microbiota composition shows a high degree of individual specificity. Analysis of transcript-bacteria interactions identifies six distinct groups of inflammation-related pathways that are associated with intestinal microbiota (adjusted P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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