Endotoxin and Cytokines Removal with Adsorption Device in a Child with Sepsis After Transplantectomy (Case Report)
| Autor: | A. A. Eremenko, T. V. Marchenko, V. V. Nikoda, A. K. Zokoev, D. A. Skripalenko |
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| Jazyk: | English<br />Russian |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Общая реаниматология, Vol 19, Iss 6, Pp 48-53 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1813-9779 2411-7110 |
| DOI: | 10.15360/1813-9779-2023-6-48-53 |
| Popis: | Sepsis is one of the leading causes of death in kidney transplant recipients.We present our experience of effective removal of bacterial endotoxins and endogenous inflammatory mediators using a multimodal hemosorbent in sepsis, caused by gram-negative polyresistant Klebsiella spp. including K. pneumoniae. The device was used in a 15 y.o. patient after treatment failure of graft-bed abscess and removal of kidney transplant.Results. Two 24-hour sorption procedures on Days 3 and 5 post-transplantectomy in combination with renal replacement therapy resulted in consistent decrease of pro-inflammatory markers concentrations (procalcitonin — 15.111.47.2 ng/ml; C-reactive protein — 23419990 mg/l), preventing therefore further progression of multiple organ dysfunctions.Conclusion. Inclusion of selective adsorption of cytokines and/or lipopolysaccharides into multimodal intensive therapy in an immunosuppressed pediatric patient with sepsis caused by resistant microorganisms improved treatment outcomes. |
| Databáze: | Directory of Open Access Journals |
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