The TRH test provides valuable information in the diagnosis of central hypothyroidism in patients with known pituitary disease and low T4 levels

Autor:	Sara Ellegaard Christensen, Liv Norma Smith, Christian Alexander H. Rosendal, Helga Angela Gulisano, Kåre Schmidt Ettrup, Peter Vestergaard, Eigil Husted Nielsen, Jesper Scott Karmisholt, Jakob Dal
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	thyrotropin-releasing hormone (TRH) pituitary disease central hypothyroidism TRH test hypopituitarism Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Frontiers in Endocrinology, Vol 14 (2023)
Druh dokumentu:	article
ISSN:	1664-2392
DOI:	10.3389/fendo.2023.1226887
Popis:	ObjectiveTo evaluate the value of the thyrotropin-releasing hormone (TRH) test in the diagnosis of central hypothyroidism (CH) in patients with pituitary disease.MethodsSystematic evaluation of 359 TRH tests in patients with pituitary disease including measurements of thyroxine (T4), TBG-corrected T4 (T4corr), baseline TSH (TSH0) and relative or absolute TSH increase (TSHfold, TSHabsolute).ResultsPatients diagnosed with CH (n=39) show comparable TSH0 (p-value 0.824) but lower T4corr (p-value
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c7d5311346ec4c369db8722a9376d88d View record in DOAJ