Bacteriophage Therapy for Pan-Drug-Resistant in Two Persons With Cystic Fibrosis
| Autor: | Andrea Hahn MD, MS, Iman Sami MD, Hollis Chaney MD, Anastassios C. Koumbourlis MD, MPH, Coralee Del Valle Mojica MD, MPH, Claire Cochrane BA, Benjamin K. Chan PhD, Jonathan L. Koff MD |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Investigative Medicine High Impact Case Reports, Vol 11 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2324-7096 23247096 |
| DOI: | 10.1177/23247096231188243 |
| Popis: | Cystic fibrosis (CF) is an important monogenic disease that affects more than 70 000 people worldwide. Defects of the CF transmembrane conductance regulator gene lead to dehydrated viscous secretions that result in chronic bacterial colonization. This leads to frequent recurrent lung infections called pulmonary exacerbations, lung inflammation, and resulting structural lung damage called bronchiectasis. Pseudomonas aeruginosa in particular is a common pathogen in persons with CF associated with increased pulmonary exacerbations, long-term lung function decline, and reduced survival. In addition, P. aeruginosa commonly develops antibiotic resistance and forms biofilms, making it difficult to treat. Here, we report the details of two patients with CF with pan-drug-resistant P. aeruginosa who were treated with a novel therapeutic strategy, bacteriophages. These cases highlight the need for further research and development of this treatment modality, including pediatric clinical trials. |
| Databáze: | Directory of Open Access Journals |
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