Type III ATP synthase is a symmetry-deviated dimer that induces membrane curvature through tetramerization

Autor: Rasmus Kock Flygaard, Alexander Mühleip, Victor Tobiasson, Alexey Amunts
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-18993-6
Popis: Mitochondrial ATP synthases are involved in shaping the mitochondrial cristae. The cryo-EM structure of type III ATP synthase reveals the architecture of the unusual, asymmetrical, U-shaped dimer and offers insights into the interaction with the natural inhibitor IF1 and membrane lipids. The structure of the enzyme tetramer suggests the mechanism of membrane curvature generation.
Databáze: Directory of Open Access Journals