| Autor: |
Afshin Kheradmand, Shayan Fallah, Mitra-Sadat Sadat-Shirazi, Ghorbangol Ashabi, Solmaz Khalifeh, Nayereh Zare |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Archives of Advances in Biosciences, Vol 15, Iss 1, Pp 1-6 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2783-1264 |
| DOI: |
10.22037/aab.v15i1.39091 |
| Popis: |
Introduction: Alzheimerʼs disease (AD) has been identified as a progressive memory and cognitive impairment. Some Salvia species are suggested by certain studies for the management of mild to moderate AD. We aimed to evaluate the anti-inflammatory, antioxidant, and anti-apoptotic effects of S. hydrangea on amyloid beta-injected rats. Materials and Methods: Rats were pretreated with S. hydrangea for 10 days before amyloid beta (Aβ) injection. Western blotting techniques were used to evaluate protein level of γ-glutamyl cysteine synthetase (γ-GCS), Tumor Necrosis Factor α (TNF-α) and Interleukin-6 (IL-6) in two brain regions: hippocampus and frontal cortex. Results: Current data show that S. hydrangea extract increased γ-GCS protein levels in amyloid beta injected rats, and pretreatment with S. hydrangea increased it further. Besides, S. hydrangea decreased protein levels of TNF-α and IL-6 in amyloid beta injected rats. Conclusion: Based on the decreased levels of IL-6, TNF-α, and the increased levels of γ-GCS, it is suggested that the use of S. hydrangea could be protective in neurodegenerative diseases. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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