Antioxidant supplementation during treatment of outpatient dogs with parvovirus enteritis ameliorates oxidative stress and attenuates intestinal injury: A randomized controlled trial

Autor: Gollahalli Eregowda Chethan, Ujjwal Kumar De, Mithilesh Kumar Singh, Vishal Chander, Raguvaran Raja, Babul Rudra Paul, Om Prakash Choudhary, Neeraj Thakur, Kalyan Sarma, Hridayesh Prasad
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Veterinary and Animal Science, Vol 21, Iss , Pp 100300- (2023)
Druh dokumentu: article
ISSN: 2451-943X
DOI: 10.1016/j.vas.2023.100300
Popis: A prospective randomized controlled clinical study was conducted to determine whether antioxidant supplementation as an adjunct therapy alters hemogram, oxidative stress, serum intestinal fatty acid binding protein-2 (IFABP-2) level, fecal viral load, clinical score (CS) and survivability in outpatient canine parvovirus enteritis (CPVE) dogs. The dogs with CPVE were randomized to one of the five treatment groups: supportive treatment (ST) alone, ST with N-acetylcysteine (ST+NAC), resveratrol (ST+RES), coenzyme Q10 (ST+CoQ10) or ascorbic acid (ST+AA). The primary outcome measures were reduction of CS and fecal HA titre, and enhancement of survivability. Secondary outcome measures were reduction of oxidative stress indices and IFABP-2 level from day 0 to day 7. The mean CS and HA titre were significantly (P
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