Phytotherapeutics oridonin and ponicidin show additive effects combined with irradiation in pancreatic cancer in vitro

Autor: Liermann Jakob, Naumann Patrick, Fortunato Franco, Schmid Thomas E., Weber Klaus-Josef, Debus Jürgen, Combs Stephanie E.
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Radiology and Oncology, Vol 51, Iss 4, Pp 407-414 (2017)
Druh dokumentu: article
ISSN: 1581-3207
DOI: 10.1515/raon-2017-0048
Popis: Chemoradiation of locally advanced non-metastatic pancreatic cancer can lead to secondary operability by tumor mass reduction. Here, we analyzed radiomodulating effects of oridonin and ponicidin in pancreatic cancer in vitro. Both agents are ent-kaurane diterpenoids, extracted from Isodon rubescens, a plant that is well known in Traditional Chinese Medicine. Cytotoxic effects have recently been shown in different tumor entities for both agents.
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