The Use of Photoactive Polymeric Nanoparticles and Nanofibers to Generate a Photodynamic-Mediated Antimicrobial Effect, with a Special Emphasis on Chronic Wounds

Autor:	Mohamed A. Abdel Khalek, Amr M. Abdelhameed, Sara A. Abdel Gaber
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	chronic wound healing polymeric nanoparticles electrospun nanofibers photodynamic therapy (PDT) Pharmacy and materia medica RS1-441
Zdroj:	Pharmaceutics, Vol 16, Iss 2, p 229 (2024)
Druh dokumentu:	article
ISSN:	1999-4923
DOI:	10.3390/pharmaceutics16020229
Popis:	This review is concerned with chronic wounds, with an emphasis on biofilm and its complicated management process. The basics of antimicrobial photodynamic therapy (PDT) and its underlying mechanisms for microbial eradication are presented. Intrinsically active nanocarriers (polydopamine NPs, chitosan NPs, and polymeric micelles) that can further potentiate the antimicrobial photodynamic effect are discussed. This review also delves into the role of photoactive electrospun nanofibers, either in their eluting or non-eluting mode of action, in microbial eradication and accelerating the healing of wounds. Synergic strategies to augment the PDT-mediated effect of photoactive nanofibers are reviewed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7d32dae82aa34f9094986f5a1b6b591f Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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