Investigation of the effect of steroidal imidazoheterocycles hormone derivatives on JEG-3 trophoblast cells of choriocarcinoma
| Autor: | Todosijević Jovana V., Scherbakov Alexander M., Volkova Yulia A., Jurišić Vladimir B. |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Kragujevac Journal of Science, Vol 2021, Iss 43, Pp 99-107 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1450-9636 2466-5509 |
| DOI: | 10.5937/KgJSci2143099T |
| Popis: | This study aimed to examine the biological activities of unique steroid hormone derivatives-steroidal imidazoheterocycles. The activity synthesized steroidal compounds were tested for the viability of JEG-3 trophoblast cells of choriocarcinoma. The results of the MTT cytotoxicity test showed that most of the examined steroidal imidazoheterocycles act proliferatively on the JEG-3 cell line, except (E, F, and J). Antiproliferative activity of these derivates is probably influenced by different substituents at position 17-C atom in the chemical structure of the hormone and by different substituents on the oxygen atom of acetamide group in the hormone molecule. In order to better confirm the antiproliferative activity of these derivatives, it is necessary to performed complex research on a large panel of cancer cell lines and by different assay. |
| Databáze: | Directory of Open Access Journals |
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