A rare case of lamotrigine-induced acute interstitial nephritis

Autor: Atul Matta, Nour Abou Assalie, Rajib K. Gupta, Maria del Pilar Morales, Ricardo Conti
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Journal of Community Hospital Internal Medicine Perspectives, Vol 6, Iss 6, Pp 1-3 (2016)
Druh dokumentu: article
ISSN: 2000-9666
DOI: 10.3402/jchimp.v6.32976
Popis: Medications, especially non-steroidal anti-inflammatory drugs and antimicrobials, have been most commonly associated with acute interstitial nephritis (AIN); antiepileptic drugs (AEDs) are rarely known to cause AIN. This is a case of a 27-year-old male who was recently started on treatment with lamotrigine for bipolar disorder and was found to have rapidly progressive renal failure. Renal biopsy features were suggestive of AIN. Lamotrigine-induced AIN was suspected to be the most likely cause. Discontinuation of the drug and treatment with steroids resulted in complete renal recovery. Lamotrigine use has been recently gaining popularity, not only as an AED but also as a mood stabilizer. With the use of this drug becoming more popular, it is important to emphasize that – although rare – AIN is one of its potential complications.
Databáze: Directory of Open Access Journals
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