| Autor: |
Houda Bahig, Ying Yuan, Abdallah S.R. Mohamed, Kristy K. Brock, Sweet Ping Ng, Jihong Wang, Yao Ding, Kate Hutcheson, Molly McCulloch, Peter A. Balter, Stephen Y. Lai, Abrahim Al-Mamgani, Jan-Jakob Sonke, Uulke A. van der Heide, Christopher Nutting, X. Allen Li, Jared Robbins, Mussadiq Awan, Irene Karam, Katherine Newbold, Kevin Harrington, Uwe Oelfke, Shreerang Bhide, Marielle E.P. Philippens, Chris H.J. Terhaard, Andrew J. McPartlin, Pierre Blanchard, Adam S. Garden, David I. Rosenthal, Gary B. Gunn, Jack Phan, Guillaume Cazoulat, Michalis Aristophanous, Kelli K. McSpadden, John A. Garcia, Cornelis A.T. van den Berg, Cornelis P.J. Raaijmakers, Linda Kerkmeijer, Patricia Doornaert, Sanne Blinde, Steven J. Frank, Clifton D. Fuller |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Clinical and Translational Radiation Oncology, Vol 13, Iss , Pp 19-23 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6308 |
| DOI: |
10.1016/j.ctro.2018.08.003 |
| Popis: |
Background: Current standard radiotherapy for oropharynx cancer (OPC) is associated with high rates of severe toxicities, shown to adversely impact patients’ quality of life. Given excellent outcomes of human papilloma virus (HPV)-associated OPC and long-term survival of these typically young patients, treatment de-intensification aimed at improving survivorship while maintaining excellent disease control is now a central concern. The recent implementation of magnetic resonance image – guided radiotherapy (MRgRT) systems allows for individual tumor response assessment during treatment and offers possibility of personalized dose-reduction. In this 2-stage Bayesian phase II study, we propose to examine weekly radiotherapy dose-adaptation based on magnetic resonance imaging (MRI) evaluated tumor response. Individual patient’s plan will be designed to optimize dose reduction to organs at risk and minimize locoregional failure probability based on serial MRI during RT. Our primary aim is to assess the non-inferiority of MRgRT dose adaptation for patients with low risk HPV-associated OPC compared to historical control, as measured by Bayesian posterior probability of locoregional control (LRC). Methods: Patients with T1-2 N0-2b (as per AJCC 7th Edition) HPV-positive OPC, with lymph node |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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