Vascular Cell Adhesion Molecule 1, Intercellular Adhesion Molecule 1, and Cluster of Differentiation 146 Levels in Patients with Type 2 Diabetes with Complications

Autor:	F. Sinem Hocaoglu-Emre, Devrim Saribal, Guven Yenmis, Guvenc Guvenen
Jazyk:	English<br />Korean
Rok vydání:	2017
Předmět:	Cell adhesion molecules CD146 Diabetes mellitus Intercellular adhesion molecule-1 Microvascular complications Vascular cell adhesion molecule-1 Diseases of the endocrine glands. Clinical endocrinology RC648-665
Zdroj:	Endocrinology and Metabolism, Vol 32, Iss 1, Pp 99-105 (2017)
Druh dokumentu:	article
ISSN:	2093-596X 2093-5978
DOI:	10.3803/EnM.2017.32.1.99
Popis:	BackgroundType 2 diabetes mellitus (T2DM) is a multisystemic, chronic disease accompanied by microvascular complications involving various complicated mechanisms. Intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and cluster of differentiation-146 (CD146) are mainly expressed by endothelial cells, and facilitate the adhesion and transmigration of immune cells, leading to inflammation. In the present study, we evaluated the levels of soluble adhesion molecules in patients with microvascular complications of T2DM.MethodsSerum and whole blood samples were collected from 58 T2DM patients with microvascular complications and 20 age-matched healthy subjects. Levels of soluble ICAM-1 (sICAM-1) and soluble VCAM-1 (sVCAM-1) were assessed using enzyme-linked immunosorbent assay, while flow cytometry was used to determine CD146 levels.ResultsSerum sICAM-1 levels were lower in T2DM patients with microvascular complications than in healthy controls (P
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