Determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in progressive systemic sclerosis
| Autor: | Batool Zamani, Kamal Esalatmanesh, Ahmad Piroozmand, seyyed Alireza Moravveji, Elham Kolbedary |
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| Jazyk: | perština |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | مجله علوم پزشکی فیض (پیوسته), Vol 27, Iss 2, Pp 202-210 (2023) |
| Druh dokumentu: | article |
| ISSN: | 3060-5806 3060-5814 |
| Popis: | Background: Systemic sclerosis (SSc) is a connective tissue disorder characterized by excessive collagen deposition in skin and internal organs. Interstitial lung disease (ILD) is a late demonstration of SSc and cytokines can contribute to the disease pathology. This study aimed to determine relation between serum levels of interleukin-6 and CRP with pulmonary involvement in SSc. Materials and Methods: After obtaining consent, demographic data and serum levels of interleukin-6 were determined in 30 SSc with (case) and 30 without pulmonary involvement (control). Duration and activity status of disease, C-reactive protein (CRP), Chest x-ray and high resolution CT-scan (HRCT), ejection fraction (EF) and echocardiography findings and pulmonary artery pressure (PAP) were determined in two groups. Data analyzed with Mann-Whitney test, Chi-square test and Fisher’s exact test. Results: Mean age of case and control group ranged 52.5±9.3 and 43.9±9.7 years respectively (P=0.001). The serum levels of IL-6 in case and control groups were 73.1±95.4 and 46.7±83.6 pg/ml (P=0.267), respectively. IL-6 levels was significantly higher in male case compared to male control (P=0.007). Duration of SSc in case and control groups was 11.6±6.4 and 7.4±4.2 years (P=0.002). Also Quantitative CRP and PAP was significantly higher in case (P=0.01 and P |
| Databáze: | Directory of Open Access Journals |
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