Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features

Autor: Andrea Ronchi, Immacolata Cozzolino, Marco Montella, Iacopo Panarese, Federica Zito Marino, Sabrina Rossetti, Paolo Chieffi, Marina Accardo, Gaetano Facchini, Renato Franco
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Cancer Medicine, Vol 8, Iss 16, Pp 6832-6840 (2019)
Druh dokumentu: article
ISSN: 2045-7634
DOI: 10.1002/cam4.2195
Popis: Abstract Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really represent extragondal primary neoplasms or rather extragondal metastasis from occult gonadal neoplasms. The actual observations suggest that EGGCTs represent a unique entity, so their biology and behavior are substantially different from gonadal counterparts. The diagnosis of EGGCTs is often challenging, and differential diagnosis is particularly wide. Nevertheless, a correct diagnosis is essential for the correct management of the patient. We summarize the state of art about EGGCTs, with particular emphasis on diagnosis and prognosis.
Databáze: Directory of Open Access Journals
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