FX06 to rescue SARS-CoV-2-induced acute respiratory distress syndrome: a randomized clinical trial

Autor:	Emmanuelle Guérin, Lisa Belin, Guillaume Franchineau, Loïc Le Guennec, David Hajage, Mamadou Hassimiou Diallo, Thomas Frapard, Lucie Le Fèvre, Charles-Edouard Luyt, Alain Combes, Stéphane Germain, Jan Hayon, Pierre Asfar, Nicolas Bréchot
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	FX06 Vascular leakage Endothelial hyperpermeability Acute respiratory distress syndrome SARS-CoV-2 Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Critical Care, Vol 27, Iss 1, Pp 1-11 (2023)
Druh dokumentu:	article
ISSN:	1364-8535
DOI:	10.1186/s13054-023-04616-1
Popis:	Abstract Background Vascular leakage is a major feature of acute respiratory distress syndrome (ARDS). We aimed to evaluate the efficacy of FX06, a drug under development that stabilizes interendothelial cell junctions, at reducing vascular leakage during SARS-CoV-2-induced ARDS. Methods This multicenter, double-blinded, randomized trial included adults with COVID-19-associated ARDS who had received invasive mechanical ventilation for
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/7d0ee03f3545421d8d48646355d062b0 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ