| Autor: |
Zambia Koukouritaki, Ioannis Mantzoros, Orestis Ioannidis, Styliani Parpoudi, Konstantinos Galanos-Demiris, Panagiotis Christidis, Manousos G. Pramateftakis, Efstathios Kotidis, Nikolaos Ouzounidis, Charalambos Dimitriadis, Stamatios Angelopoulos |
| Jazyk: |
English<br />Spanish; Castilian |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Cirugía y Cirujanos, Vol 89, Iss 6 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2444-054X |
| DOI: |
10.24875/CIRU.20001023 |
| Popis: |
Aim: The purpose of the study was to evaluate the effect of oral administration of n-3 polyunsaturated fatty acids in experimental ischemic enteritis in rats. Methods: Forty Wistar rats were submitted to control narrowing of the superior mesenteric artery and were divided in two groups: N3 polyunsaturated fatty acids, which received a high-molecular polymer solution of artificial total enteral nutrition enriched with n-3 fatty acids and CONTROL which received a high-molecular polymer solution of artificial total enteral nutrition. Results: Reduction of the animals’ body weight was observed in both groups, but there was no difference between the two groups. Regarding the level of cytokines interleukin (IL)-1b, IL-6, and tumor necrosis factor a (TNF-a) there was no statistically significant difference between the two groups. Ischemic lesions to the small bowel mucosa were observed in both groups. A statistically significant difference in the extent of intestinal lesions was observed between the two groups with the animals that received enteral nutrition enriched with n-3 fatty acid developing fewer lesions. Conclusion: Enteral nutrition enriched with n-3 polyunsaturated fatty acids reduces the mucosal lesions caused by mesenteric ischemia compared to standard enteral nutrition, by modifying the local, but not the systemic, immune, and inflammatory response. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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