| Autor: |
Anne T Gelderloos, Anke J Lakerveld, Rutger M Schepp, Mioara Alina Nicolaie, Josine vanBeek, Lisa Beckers, Robert S vanBinnendijk, Nynke Y Rots, Puck B vanKasteren |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Clinical & Translational Immunology, Vol 13, Iss 8, Pp n/a-n/a (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2050-0068 |
| DOI: |
10.1002/cti2.1521 |
| Popis: |
Abstract Objectives Increasing evidence suggests that Fc‐mediated antibody effector functions have an important role in protection against respiratory viruses, including SARS‐CoV‐2. However, limited data are available on the potential differences in the development, heterogeneity and durability of these responses in children compared to adults. Methods Here, we assessed the development of spike S1‐specific serum antibody‐dependent cellular phagocytosis (ADCP), complement deposition (ADCD) and natural killer cell activation (ADNKA), alongside specific antibody binding concentrations (IgG, IgA and IgM) and IgG avidity in healthy adults (n = 38, 18–56 years) and children (n = 21, 5–16 years) following primary SARS‐CoV‐2 infection, with a 10‐month longitudinal follow‐up. Differences between groups were assessed using a nonparametric Kruskal–Wallis test with Dunn's multiple comparisons test. Results We found similar (functional) antibody responses in children compared to adults, with a tendency for increased durability in children, which was statistically significant for ADCD (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
|
Nepřihlášeným uživatelům se plný text nezobrazuje |
K zobrazení výsledku je třeba se přihlásit.
|
