Tankyrase-1-mediated degradation of Golgin45 regulates glycosyltransferase trafficking and protein glycosylation in Rab2-GTP-dependent manner

Autor: Xihua Yue, Neeraj Tiwari, Lianhui Zhu, Hai Dang Truong Ngo, Jae-Min Lim, Bopil Gim, Shuaiyang Jing, Yijing Wang, Yi Qian, Intaek Lee
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-17 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02899-0
Popis: Xihua Yue et al. report that Tankyrase-1 controls poly-ADP-ribosylation of Golgin45, a Golgi structural protein, which has a profound influence on glycosyltransferase trafficking and protein glycosylation at the Golgi. This may shed new light onto mechanisms involved in development and oncogenic transformation.
Databáze: Directory of Open Access Journals