A retrospective case notes review of the effectiveness and tolerability of metoclopramide in the treatment of clozapine-induced hypersalivation (CIH)

Autor: Cecilia Livermore, Hannah White, Loren Bailey, Ian Osborne, Ebenezer Oloyede, Olubanke Dzahini, Eromona Whiskey
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Psychiatry, Vol 22, Iss 1, Pp 1-6 (2022)
Druh dokumentu: article
ISSN: 1471-244X
DOI: 10.1186/s12888-022-03940-0
Popis: Abstract Objective The objective of the study is to explore the long-term effectiveness and tolerability of metoclopramide in the treatment of CIH. Method This study is a retrospective, observational cohort study of patients prescribed metoclopramide for CIH at the South London & Maudsley (SLaM) NHS Foundation Trust. Results Of the 96 patients identified, 14 patients were eligible for inclusion in our study. Five patients continued treatment with a mean duration of 27 months (SD = 17.8), and one patient continued until transfer with a duration of 3 months. Eight patients discontinued treatment after a mean duration of 8 months. Conclusion Metoclopramide may be an effective and tolerated drug in CIH, but more data is required to establish its place in the pharmacotherapy of this condition.
Databáze: Directory of Open Access Journals
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